Site updated 07.01.2022

Emerson Stokes Research Group Archive

Research Papers
Chemistry 2022 
Dr. M. Sharma's paper on boronic acid activation by tridentate NHC copper(II) complexes was published in MDPI's journal Chemistry. This invited paper showcases optimized conditions for the conversion of boronic acids to phenols. This work also highlights conditions that do not favor this process when targeting other C-C or C-N bond forming reactions. [Click on the image above to link to the paper.] Congrats to Mitu and all who contributed!

Mitu Sharma, Bhupendra Adhikari, Raymond Femi, Amanda M. Perkins, Alison K. Duckworth, Bruno Donnadieu David O. Wipf, Sean L. Stokes, Joseph P. Emerson,Copper(II) NHC catalyst for the formation of phenol from arylboronic acids, Chemistry 2022, 4(2), 560-575;  

Inorganic Chemistry 2022 
K. McConnell's paper correlating metal ion coordination to protein orginization was published in Inorganic Chemistry! This collaborative effort between the ESRG and Nick Fitzkee's group showcases how metal ion coordination can lead to protein orginization and apprently in some cases it can lead to disorginization too. [Click on the image above to link to the paper.] Congrats Kayla!

Kayla D. McConnell, Nicholas C. Fitzkee, Joseph P. Emerson, Metal Ion Binding Can Induce Local Folding and Unfolding in Human Carbonic Anhydrase II, Inorganic Chemistry 2022, 61 1249-1253. Doi:10.1021/acs.inorgchem.1c03271  

Catalysis Communication 2021 
D. Wolgemuth's paper on olefin aziridination in water using a Mn-TmPyP4 catalyst was published! This marks the group's first effort to use water sobuble porphyrin complexes to conduct organic transformations. [Click on the image above to link to the paper.] Congrats to Danny and all who contributed!

Daniel K. Wolgemuth, Sydnee D. Elmore, James D. Cope, Patrick E. Sheridan, Sean L. Stokes, Joseph P. Emerson, Manganese-Catalyzed Aziridination of Olefins with Chloramine-T in Water and Buffered Aqueous Solutions. Cat Comm 2021, 150 106275. Doi 10.1016/j.catcom.2020.106275 

Organometallics 2020
J. Cope's paper characterizing our first tetradentate copper(II) N-heterocyclic carbene complex was published in Organometallics! This marks the group's first new copper(II) complex that shows good CEL chemistry. [Click on the image above to link to the paper.] Congrats to James and all who contributed!

James D. Cope, Patrick E. Sheridan, Christopher J. Galloway, Raymond Femi Awoyemi, Sean L. Stokes, Joseph P. Emerson, Synthesis and characterization of a tetradentate, N-heterocyclic carbene copper(II) complex and its use as a Chan-Evans-Lam coupling catalyst. Organometallics 2020, 39 (24) 4457-4464. Doi: 10.1021/acs.organomet.0c00552 

Earlier work from the ESRG

Streptococcus pneumoniae metal homeostasis alters cellular metabolism.
Lindsey R. Burcham, Rebecca A. Hill, Rachel C. Caulkins, Joseph P. Emerson, Bindu Nanduri, Jason W. Rosch, Nicholas C. Fitzkee, Justin A. Thornton, Metallomics, 2020, 12, 1416-1427. doi: 10.1039/D0MT00118J

Tuning the Copper(II)/Copper(I) Redox Potential for More Robust Copper-Catalyzed C–N Bond Forming Reaction.
James D. Cope, Henry U. Valle, Ruby S. Hall, Ekta Goel, S. Biswas, Michael P. Hendrich, David O. Wipf, Sean L. Stokes, Joseph P. Emerson, European Journal of Inorganic Chemistry 2020; 2020(14):1278-1285. doi: 10.1002/ejic.201901269.

Thermodynamics of iron(II) and substrate binding to the ethylene-forming enzyme.       
Mingjie Li, Salette Martinez, Robert P. Hausinger, Joseph P. Emerson, Biochemistry 2018; 57:5696-5705. doi: 10.1021/acs.biochem.8b00730.

Synthesis, Characterization, and Structure of a [(phen)2Cu(OTf)]OTf Complex; An Efficient Nitrogen Transfer Pre-catalyst. 
Henry U. Valle, Kathleen M. Riley, Dylan E. Russell, Daniel K. Wolgemuth, Shanterell L. Redd, Sean L. Stokes, Joseph P.   
Emerson, ChemistrySelect 2018; 22:1123-1135. doi: 10.1002/slct.201800588

The Irving William series and the 2-His-1-carboxylate facial triad: A thermodynamic study of Mn2+, Fe2+, and Co2+ binding to taurine/α-ketoglutarate dioxygenase (TauD).
Mingjie Li, Kate L. Henderson, Salette Martinez, Robert P. Hausinger, Joseph P. Emerson, Journal of Biological Inorganic   
Chemistry, 2018; doi: 10.1007/s00775-018-1574-4.  

Resolving Distinct Molecular Origins for Copper Effects on PAI-1 
Joel C. Bucci, Carlee S. McClintock, Yuzhuo Chu, Gregory L. Ware, Kayla D. McConnell, Joseph P. Emerson, Cynthia B. 
Peterson, Journal of Biological Inorganic Chemistry, 2017; 22:1123-1135. doi:10.1007/s00775-017-1489-5

Global Stability of an α-Ketoglutarate-Dependent Dioxygenase (TauD) Using Differential  Scanning Calorimetry 
Kate L. Henderson, Mingjie Li, Salette Martinez, Robert P. Hausinger, Joseph P. Emerson, Biochimica Biophysica Acta 2017; 1851-994. doi: 10.1016/j.bbagen.2017.02.018

ITC Methods for Assessing Buffer/Protein Interactions using Steady-State Kinetics: A reactivity study of Homoprotocatechuate 2,3-Dioxygenase
Kate L. Henderson, Delta K. Boyles, Vu H. Le, Edwin A. Lewis, and Joseph P. Emerson, Methods in Enzymology 2016; 567; 257-78. doi: 10.1016/bs.mie.2015.08.034

Calorimetric and spectroscopic investigations of the binding of metallated porphyrins to G-quadruplex DNA 
Jesse I. DuPont, Kate L. Henderson, Amanda Metz, Vu H. Le, Joseph P. Emerson, Edwin A. Lewis, Biochimica Biophysica Acta 2015 1860(5):902-9. doi: 10.1016/j.bbagen.2015.09.004.
Thermodynamics of Substrate Binding to the Metal Site in Homoprotocatechuate 2,3-Dioxygenase: Using ITC under anaerobic conditions to study enzyme-substrate interactions
Kate L. Henderson, Danielle H. Francis, Edwin A. Lewis, Joseph P. Emerson, Biochimica Biophysica Acta, 2015 1860(5):910-6. doi: 10.1016/j.bbagen.2015.07.013
Characterization of the Copper(II) Binding Sites in Human Carbonic Anhydrase II.  
Whitnee L. Nettles, He Song, Nicholas C. Fitzkee, Joseph P. Emerson, Inorganic Chemistry, 2015 54(12), 2278-2283. DOI: 10.1021/acs.inorgchem.5b00057
Iodide-Induced Organothiol Desorption and Photochemical Reaction, Gold Nanoparticle (AuNP) Fusion, and SERS Signal 
Reduction in Organothiol-Containing AuNP Aggregates  
Ganganath S. Perera, Allen LaCour, Yadong Zhou, Kate L. Henderson, Shengli Zou, Felio Perez, Joseph P. Emerson,     Dongmao Zhang, Journal of Physical Chemistry C, 2015 1119(8), 4261-4267. DOI: 10.1021/jp512168z
Calorimetric Assessment of Fe2+ Binding to α-Ketoglutarate/Taurine Dioxygenase: Ironing Out the Energetics of Metal 
Coordination by the 2-His-1-Carboxylate Facial Triad
Kate L. Henderson, Tina Müller, Robert Hausinger, Joseph P. Emerson, Inorganic Chemistry, 2015 54(5), 2278-2283. Doi: 
Building reactive copper centers in human carbonic anhydrase II
He Song, Andrew C. Weirtz, Michael P. Hendrich, Edwin A. Lewis, Joseph P. Emerson, Journal of Biological Inorganic 
Chemistry, 2013 18(6), 595-598 
Joseph P. Emerson, Vu H. Le, Edwin A. Lewis, eLS (Encyclopedia of Life Sciences), 2012 John Wiley & Sons Ltd,
Revisiting Zinc Binding in Human Carbonic Anhydrase
He Song, David L. Wilson, Erik R. Farquhar, Edwin A. Lewis, Joseph P. Emerson, Inorganic Chemistry, 2012 51(20),    
Exploring Substrate Binding in Homoprotocatechuate 2,3-Dioxygenase using Isothermal Titration Calorimetry  
Kate L. Henderson, Vu H. Le, Edwin A. Lewis, Joseph P. Emerson, Journal of Biological Inorganic Chemistry, 2012 17(7), 991-4.

In vivo Self-Hydroxylation of an Fe-Substituted Manganese Dependent Extradiol Dioxygenase
Erik R. Farquhar, Joseph P. Emerson, Kevin D. Koehntop, Milena Trmcic, Mark Reynolds, Lawrence Que, Jr., Journal of 
Biological Inorganic Chemistry, 2011, 16(4), 589-97  
Human deoxyhypusine hydroxylase, an enzyme that regulates cell growth, has a nonheme diiron active site that binds O2.
Van V. Vu, Joseph P. Emerson, Marlène Martinho, Yeon S. Kim, Eckard Munck, Myung H. Park, Lawrence Que, Jr.,        
Proceedings of the National Academy of Sciences, U.S.A.; 2009, 106(35), 14814-9.
Electron Paramagnetic Resonance Detection of Intermediates in the Enzymatic Cycle of an Extradiol Dioxygenase.  
William A. Gunderson, Anna I. Zatsman, Joseph P. Emerson, Erik R. Farquhar, Lawrence Que Jr., John D. Lipscomb, Michael P. Hendrich, Journal of the American Chemical Society; 2008, 130, 14465–7 
Synthesis, X-Ray Crystallographic Characterization, and Electronic Structure Studies of a Di-Azide Iron(III) Complex: Implications for the Azide Adducts of Iron(III) Superoxide Dismutase  
Laurie E. Grove, Jason K. Hallman, Joseph P. Emerson, Jason A. Halfen, Thomas C. Brunold, Inorganic Chemistry; 2008, 47, 5762-74
Swapping Metals in Fe- and Mn-Dependent Dioxygenases. Evidence for Oxygen Activation Without a Change in Metal Redox State.  
Joseph P. Emerson, Elena G. Kovaleva, Erik R. Farquhar, John D. Lipscomb, d Lawrence Que, Jr., Proceedings of the 
National Academy of Sciences, U.S.A.; 2008, 105, 7347-52 
Reaction of Desulfovibrio vulgaris Two-Iron Superoxide Reductase with Superoxide: Insights from Stopped-flow Spectrophotometry.  
Victor W. Huang, Joseph P. Emerson, Donald M. Kurtz, Jr., Biochemistry; 2007, 46, 11342 – 51

Structural “Snap-Shots” along Reaction Pathway of Non-heme Iron Enzymes  
Joseph P. Emerson, Erik R. Farquhar, Lawrence Que, Jr., Angewandte Chemie International Edition; 2007, 46; 8553 – 6
 “Schnappschüsse” von Strukturen entlang der Reaktionswege von Nicht‐Häm‐Eisenenzymen
 Joseph P. Emerson, Erik R. Farquhar, Lawrence Que, Jr., Angewandte Chemie; 2007, 119 (45), 8705-8708
Post-translational self-hydroxylation: a probe for oxygen activation mechanisms in non-heme iron enzymes  
Erik R. Farquhar, Kevin D. Koehntop, Joseph P. Emerson, Lawrence Que, Jr., Biochemical and Biophysical Research 
Communications; 2005, 338; 230 – 9
The Role of Histidine 200 in MndD, the Mn(II)-dependent 3,4-Dihydroyphenylacetate 2,3-Dioxygenase from Arthrobacter globiformis CM-2 from Site-Directed Mutagenesis Studies.  
Joseph P. Emerson, Michelle L. Wagner, Mark F. Reynolds, Lawrence Que, Jr. Michael J. Sadowsky, Lawrence P. Wackett, Journal of Biological Inorganic Chemistry; 2005, 10; 751-760 
The 2-His-1-Carboxylate Facial Triad: A Versatile Platform for Dioxygen Activation at Mononuclear Nonheme Iron(II) 
Kevin D. Koehntop, Joseph P. Emerson, Lawrence Que, Jr., Journal of Biological Inorganic Chemistry; 2005, 10(2); 87-93
Iron Enzymes with Mononuclear Nonheme Active Sites.  
Joseph P. Emerson, Mark P. Mehn, Lawrence Que, Jr., Encyclopedia of Inorganic Chemistry II; John Wiley & Sons, Inc.; 2005
Kinetics of the Superoxide Reductase Catalytic Cycle.  
Joseph P. Emerson, Eric D. Coulter, Robert S. Phillips, Donald M. Kurtz, Jr., Journal of Biological Chemistry; 2003; 278(41); 39662-8
Spectroscopic Characterization of the [Fe(NHis)4(SCys)] site in 2Fe-Superoxide Reductase for Desulfovibrio vulgaris   
Michael D. Clay, Joseph P. Emerson, Eric D. Coulter, Donald M. Kurtz, Jr., Michael K. Johnson, Journal of Biological Inorganic Chemistry, 2003; 8; 671-82 
An Engineered Two-Iron Superoxide Reductase Lacking the [Fe(SCys)4] Site Retains its Catalytic Properties in vitro and in vivo.  
Joseph P. Emerson, Diane E. Cabelli, Donald M. Kurtz, Jr., Proceedings of the National Academy of Sciences, U.S.A.; 2003; 100, 3802-7 
Kinetics and Mechanism of Superoxide Reduction by Two-Iron Superoxide Reductase from Desulfovibrio vulgaris.  
Joseph P. Emerson, Eric D. Coulter, Diane E. Cabelli, Robert S. Phillips, Donald M. Kurtz, Jr., Biochemistry; 2002; 41(13); 4348-57
Superoxide Reactivity of Rubredoxin Oxidoreductase (Desulfoferrodoxin) from Desulfovibrio vulgaris: A Pulse Radiolysis 
Eric D. Coulter, Joseph P. Emerson, Donald M. Kurtz, Jr., Diane E. Cabelli, Journal of the American Chemical Society; 2000; 122(46); 11555-6. DOI: 10.1021/ja005583r
Remarkably Efficient Olefin Aziridination Mediated by a New Copper(II) Complex  
Jason A Halfen, Jason K. Hallman, John A. Shultz, Joseph P. Emerson, Organometallics; 1999; 18(26); 5435-7. DOI: 10.1021/om9908579